Lotseril - instructions for use. Loceryl - varnish from nail fungus: instructions for use, reviews, analogues, price Loceryl from pressure

Lotseril: instructions for use and reviews

The external environment is aggressive to human health, as it is also inhabited by harmful microorganisms. There are about five hundred species of fungal strains that can infect humans. They affect the skin, hair, internal organs. Some of the fungi are able to settle on the nails of the hands and feet, resulting in the development of a disease such as onychomycosis.

This disease is quite difficult to treat, it requires long-term therapy, which consists in treating the nail with various preparations - ointments, creams and varnishes. Today we will talk about just such a medicine - a varnish called Loceryl.

In fact, although this medicine is called varnish, it is rather a special medicinal solution that causes the death of the fungus. But the way it is applied - with a brush or spatula - has led to the fact that most often the drug is called varnish. The vial may contain 2.5 mm or 5 mm solution.

The varnish is applied with a special spatula 2-3 times a week, leaving to dry for 3-5 minutes until completely absorbed. Rules for the use of the drug:

1. Before applying the solution, it is necessary to prepare the nails - steam them in a bath with salt or soda.
2. With a special nail file, it is necessary to remove the most damaged parts of the nail plate, and cut the nails themselves as short as possible.
3. Dry your nails with a clean towel until they are completely dry.
4. Degrease nails with a special swab.
5. With a spatula, which is also present in the kit, apply the product in a thick layer on the nails and leave until completely absorbed. This usually takes 3 to 5 minutes.

On average, the initial stage treatment can take up to 2 months. With more neglected foci, the solution will have to be applied for at least six months.

The effect of varnish on nail fungus

The causative agent of onychomycosis is a microorganism that has a protein structure and a fairly dense membrane. To combat it, Loceryl is used - an antifungal drug for external use. The solution, which is applied with a special spatula, has a fungistatic and fungicidal effect, based on a change in the cell membrane of the fungus by disrupting the biosynthesis of sterols. The active substance of the drug is amorolfine, which inhibits 2 different enzymes involved in the biosynthesis of ergosterol - delta14-reductase and delta7-delta8-isomerase. Amorolfine has a wide spectrum of action, it is active against fungi of the genus Candida, Pityrosporum, Cryptococcus, Trichophyton, Microsporum, Epidermophyton, Alternaria, Hendersonula, Scopulariopsis, Cladosporium, Fonseceae, Wangiella, Coccidioides, Histoplasma, Sporothrix.

Despite the fact that the drug is also considered antibacterial, it only shows its activity against the bacteria Actinomyces.

Thus, at the cellular level, Loceryl destroys the membrane of the fungus, after which the microorganism dies.

Indications for use

This tool is used only for the treatment of nail fungus or prevention. Monotherapy, that is, the use of only this drug, is indicated under the condition that the focus of the fungus spreads to no more than 30% of the nail plate.

For prevention, the drug is best applied no more than once a week.

Contraindications

Since the drug is practically not found in the blood plasma, its contraindications are minimal. The manufacturer does not recommend the use of varnish in the following cases:

• children's age (the effect of the drug on the child's body has not been studied).
• individual intolerance to the components of the drug.

Also, do not use Loceryl during pregnancy and breastfeeding. In all other cases, the drug can be used. Before use, it is advisable to consult a doctor about dosage and complex therapy.

Side effects

When using Loceryl varnish, local reactions are possible, which include:

• hyperthermia;
• redness;
• rash;
• peeling of the skin around the edges of the nails.

An increase in side effects is observed with an overdose of the drug and its use more often than once every 2 days. Local allergic reactions are also possible. If any unpleasant symptoms occur, you should stop using the drug and consult a dermatologist who will select another drug for treatment.

Precautionary measures

In order for the treatment to lead to the desired result, it is necessary to know and follow the precautions.

1. Apply the drug to the nail plate, bypassing the skin. Skin contact may cause redness and irritation.
2. Use disposable nail files, and if you use reusable metal files, wipe them with a disinfectant after each use.
3. Do not use scissors and files for healthy nails, which you used to treat diseased nails.
4. If another person is engaged in the processing of nails, he must do this with gloves in order to prevent infection.

When treating toenails, it is necessary to pay great attention to hygiene - avoid wearing synthetic socks, tight shoes, wash your feet in time, fight sweating.

If you follow these precautions, your nails will quickly return to normal.

Application duration

The duration of the use of Loceryl depends on the immunity of the patient, and on the degree of damage to the nail plate. At the initial stage of treatment, the drug is applied to pre-steamed, washed and filed nails 3 times a week for 1-2 months. With more advanced stages, treatment can be carried out up to six months. Based on the results of treatment, it is necessary to contact a dermatologist who will take a microparticle of the nail for analysis and determine if there is a fungus. Even if the analysis showed complete recovery, it should be repeated after 2 weeks. If the negative result is repeated, the treatment is stopped, and the patient is considered to have fully recovered.

• At the initial stage, with damage to 10-15% of the nail - 1 month.
• With damage to 30% of the nail - 2 months.
• With damage to 50% of the nail - up to six months.
• If more than 50% of the nail is affected, Loceryl should be used as part of complex therapy.

Price

The cost of Loceryl differs in different pharmacies. On average, the price for a jar of 2.5 mm is 1100-1500 rubles. The price for a jar of 5 ml reaches 3,000 rubles.

Maria: “As prescribed by a dermatologist, I used this varnish. It is not cheap, but when compared with other means, its consumption is very small, so the course of treatment was acceptable. The fungus disappeared already in the third month, but the doctor said to smear further 3 times a week until the remedy runs out. The fungus has gone completely and is not coming back.”

Lotseril analogs

If for some reason Loceryl is not available to you, you can purchase one of two well-known analogues: or Cyclocutane.

Oflomil

An antifungal drug that quickly penetrates deep into the nail plate and remains in the focus of mycosis for a long time at a concentration that is detrimental to harmful microorganisms. It helps to get rid of onychomycosis of the nails, destroying most of the known fungi that lead to the destruction of the dermis and nails. Oflomil, as an analogue of Loceril, acts at the cellular level, destroying the membrane due to active enzymes. It can be used both for the treatment of various stages of the fungus, and for the prevention of healthy nails.

Sold in a set that includes cotton swabs soaked in alcohol, 12 nail files, a bottle of varnish, applicators for applying the solution, instructions with a description of the drug.

Cyclocutane

Another antifungal drug for external use, which has a fungistatic and fungicidal effect. It was specially developed for the treatment of fungal infections of the nails. The active substance ciclopirox is able to penetrate deeply directly into the nail plate, destroying all pathogens of fungal infections. It is used for any strains of microorganisms that affect the nail plate. Able to defeat the fungus at any stage.

Before treatment, you should consult a doctor. Usually, during the first month, the solution is applied in a thin layer daily to the affected nails. From the second month, the algorithm is changed and the solution is applied every 2 days. Continue treatment until the solution runs out, after which they do an analysis that should confirm complete recovery.

More information on how to use this drug is written in the instructions that come with the kit.

Also among the analogs for the action on the fungus, Dactanol can be distinguished; Diflazon; Diflucan; Itrazol; Itramikol; Amphotericin B; Anmarin; Atifin; Batrafen; Binafin; Bifonazole and other drugs.

Application for prevention

Loceryl can be used to prevent recurrence after suffering a nail fungus. To do this, lubricate the nails after therapy once a week until the drug is over. Also, if people with weakened immune systems live in the room, and someone from the family has a nail fungus, you can use Loceryl to treat healthy nails to prevent infection. In order to prevent healthy nails, the drug is applied 1 time in 10 days.

To prevent the disease from returning, it is important to prevent re-infection. To do this, it is necessary to prevent the use of manicure tools without treatment, observe the rules of hygiene, and treat nails in time.

Interaction with other drugs

There is no information about the interaction of Loceryl with other drugs.

If you are taking or using other medicines, including over-the-counter medicines and birth control pills, please ask your doctor or pharmacist for advice.

Content

Onychomycosis is a fungal infection of the nail plates that is difficult to treat. Its therapy is carried out with local and systemic drugs, if necessary, the removal of the nail is carried out. The French manufacturer of aesthetic dermatology products Laboratories Galderma offered its solution to the problem - antifungal varnish Lotseril.

Composition and form of release of varnish Lotseril

Antifungal varnish is an external antimycotic - a drug used to prevent and treat fungal infections. Its active component is a substance of the morpholine group - amorolfine. As excipients in Loceryl, methacrylic acid ester (methyl methacrylate), ethyl acetate, triacetin, butyl acetate, absolute ethanol are used.

Lacquer Loceryl from the fungus is produced in the form of a transparent viscous solution, sold in dark glass bottles. The kit contains an insert made of polymeric material to protect the drug from drying out, 30 swabs moistened with isopropyl alcohol and packed in sealed aluminum foil envelopes, 30 disposable files, 10 plastic spatulas, instructions for use.

Pharmacological properties

Amorolfine has a wide spectrum of activity, is active against fungi of the genus Candida, Pityrosporum, Scopylariopsis, Sporothrix. Bacteria are not sensitive to the substance. Amorolfine is almost not determined in the blood, its systemic absorption is negligible. Lac Loceryl based on amorolfine has a deep prolonged effect on the diseased plate. It conducts the antimycotic substance deep into, to the very bed of the nail, the effect of its single application lasts several days. The active substance Loceryl has 2 types of action:

1. Fungistatic - helps to delay and stop the growth of fungi. After the cessation of the fungistatic effect, the development of the microorganism resumes.
2. Fungicidal - destroying the fungal cell by inhibiting (suppressing) the synthesis of sterols (polycyclic alcohols found in the cell membrane), blocking enzymes that restore their vital activity.

Indications for use

Lac Loceryl is effective in the prevention, mono- and complex therapy of nail lesions caused by fungi, many of which are dimorphic (in nature they live like mold, and in the human body - like yeast). The following types of microorganisms are sensitive to amorolfine:

• dermatophytes - Micosporum, Trichophyton, Epidermophyton;
• yeast-like fungi - Candida, Cryptococcus, etc.;
• mold fungi - Acremonium, Aspergillus, Penicillium, etc.

Monotherapy with Loceryl is indicated if no more than 2/3 of the area of ​​the nail plate is affected and the duration of the disease does not exceed 1 year. Lacquer is effective for the following lesions:

• marginal - an early stage of mycosis, when there are barely noticeable defects in the area of ​​\u200b\u200bthe free edge of the nail;
• normotrophic - defects in the nail plates in the form of stripes with pronounced fragility, discoloration to yellow-gray, without thickening;
• hypertrophic - characterized by thickening of the nail and subungual hyperkeratosis (keratinization), indicating a long-term course of the disease without treatment;
• proximal deforming - characterized by a wave-like defect;
• atrophic - thinning of the layers of the nail plate;
• white surface form - with the formation of small, but rapidly progressive white spots on the upper layers.

Contraindications and side effects

Amorolfine is a non-toxic drug, but the use of Loceryl varnish can cause redness, burning and itching in the area of ​​\u200b\u200bthe nail plate, on the skin around it. In rare cases, dermatitis of adjacent skin areas may occur. Contraindications to the use of medicinal varnish are:

• intolerance to amorolfine or any of the excipients;
• pregnancy or the period of breastfeeding;
• childhood.

Mode of application

Lacquer Loceryl is applied to the surface of the infected nail during the first month of treatment 2 times, the second month - 1 time per week. The duration of the course depends on the rate of growth of a healthy nail plate: the treatment of onychomycosis on the hands can last up to 6, on the legs - 6-12 months. Monotherapy with amorolfine will only be effective under the following conditions:

• The duration of the disease does not exceed 1 year.
• The type of lesion is not hypertrophic - due to the long-term course of onychomycosis without treatment.
• The area of ​​infection does not exceed 2/3 of the nail plate.

Otherwise, external treatment is recommended to be combined with systemic therapy - taking an antifungal agent inside. In the treatment of candidal onychomycosis of the hands, fluconazole is effective. Terbinafine and Itraconazole show good results in the fight against fungus. It is better if systemic treatment is started earlier than local treatment - the most effective is the scheme when the varnish is administered after 2/3 of the course of systemic treatment.

After the end of therapy for 1 year, it is necessary to monitor the condition of the nail plates: at least once every 3 months, conduct a microscopic examination for fungi. If the infection continues to be detected, it is necessary to repeat the course of treatment, based on systemic agents of a different chemical group. It is recommended to start therapy again 5-6 months after the end of the main course.

Before each use of Loceryl, it is necessary to cut off the diseased areas as much as possible with scissors, process with a file, remove dirt and microparticles, wipe the surface of the plate with a swab. Lacquer should be applied with a spatula to all diseased nails, let it dry for 3 minutes. Files that have processed infected plates should not be used to work with healthy nails. During treatment with Loceryl, cosmetic varnish and artificial nails cannot be used.

Lotseril's analogs

There is no synonym for the drug based on amorolfine. There is another varnish on sale that has an effect similar to Loceryl - Batrafen, but it is based on a different active substance. There are a large number of antifungal ointments used in the treatment of onychomycosis, they act superficially, without penetrating deep to the nail bed. When treating a fungal infection with an ointment, the doctor must expose the nail bed. Among the popular antifungal local remedies are the following:

1. Atifin (Slovenia) - antifungal cream containing terbinafine hydrochloride. It exhibits fungicidal activity in small concentrations, has a low systemic effect. It is applied to the affected area 2 times a day for 1 week.
2. Batrafen (Germany) is an analogue of Loceryl in the form of a varnish based on ciclopirox. Active against a wide range of fungi. Before the first use, it is necessary to remove the maximum possible affected area with scissors, and make the rest of the surface rough.
3. Lamisil (Switzerland) is an antifungal cream based on terbinafine. It has a fungicidal effect on dermatophytes and mold fungi, in relation to yeast it can exhibit both fungicidal and fungistatic activity. Apply to the affected area 1 time per day for 1 week.
4. Diflucan (France) is a drug for systemic use in the form of capsules and solution for intravenous infusions based on fluconazole. Highly effective against Candida species, rapidly absorbed from the digestive tract, the maximum concentration in the blood is reached 1 hour after ingestion. Well tolerated, does not form active metabolites, excreted by the kidneys.
5. Exoderil (Austria) - a cream containing synthetic antimycotic naftifine hydrochloride for use in interdigital mycosis and onychomycosis. The application is performed 1 time per day on the affected area and the adjacent healthy area of ​​skin 1 cm wide. The duration of treatment is 2-4 weeks, depending on the stage of the disease.

The price of Loceryl

Medical varnish is sold in stationary and online pharmacies of the capital in bottles of 2.5 and 5 ml. The cost of Loceril in pharmacies is high, the price range is significant - from 800 rubles. for a bottle of 2.5 ml up to 2500 rubles for 5 ml of the drug. The difference in prices at the same dosage can be explained by commercial surcharges of suppliers:

Video

One can especially note the solution "Lotseril". The instruction to it recommends using this medicine as an external remedy. It refers to potent drugs used for prophylaxis and there are two very convenient dosage forms of this drug. The most convenient for use is Loceryl nail polish. It is produced in bottles of 2.5 and 5 ml. The drug contains the active substance - a 5% solution of amolorphine. Another equally convenient form of release is a 5% solution in 2.5 and 5 ml vials. To date, there is no other data on other forms of release of the drug "Loceryl". Tablets, creams and ointments under this name are not sold in pharmacies. 1 ml of solution contains 50 mg of active substance. Auxiliary substances in the preparation are triacetin, methacrylic acid copolymers, ethyl acetate, ethanol, butyl acetate. In packages with this medicine, there are 16 tampons for cleaning nails, 10 special spatulas, 30 disposable nail files.

Indications for use are fungal infections of the nails caused by different types of fungi. In monotherapy, the drug is used when no more than 2/3 of the nail is affected. Prevention of fungal infections can be carried out continuously.

The drug "Loceryl", the instructions for use of which guarantees a relatively quick disposal of the fungus and its prevention, have a rather high cost, although health costs such money. This drug has a fungicidal, fungistatic effect on pathogens. The active substance - amolorfin - changes the state of the cell membrane of the fungus by disrupting its sterol biosynthesis. The active substance of the drug is able to inhibit two different enzymes involved in the synthesis of ergosterol - delta7-8-isomerase and delta-14-reductase. Amolorfin is active against the vast majority of fungi that cause nail diseases.

The drug "Loceryl", instructions for use

Varnish and solutions are applied to the affected nail plates of the fingers of the extremities 1-2 p. in Week. Active substances penetrate the nail plate in 24 hours. Treatment continues until the complete regeneration of the nails and the cure of the fungal disease. Usually therapy lasts up to 6 months. In especially severe cases, it is extended up to 12 months. The application of the drug "Loceryl" instruction recommends starting with the preparation of nails. To do this, the affected areas of the nail plate are removed as much as possible using the nail file attached to the medication. The next stage of processing is cleaning the surface of the nail and degreasing it with a swab dipped in alcohol. This procedure should be carried out before each application of the drug. The drug "Loceryl" (solution and varnish) is applied to the entire surface of the nail with a special spatula that comes with the medicine. The drug dries in a few minutes. Treat all affected nail plates. Files used in the treatment of diseased nails are not used to care for healthy ones.

By-effect

During the use of the drug in the places of its application, burning, itching, hyperemia are possible.

Contraindications:

Sensitivity to the chemicals that make up the drug;

lactation period;

Pregnancy;

Childhood.

To protect the treated nails while working with any organic solvents, you need to wear it. During treatment with Loceryl, the instructions for it categorically prohibit the use of cosmetic varnish.

The shelf life of the drug is 3 years. It is stored in a closed container at a temperature not exceeding 30°C.

Name:

Loceryl (Loceryl)

Pharmacological
action:

pharmachologic effect: Antifungal drug for external use. It has a fungistatic and fungicidal effect due to damage to the cytoplasmic membrane of the fungus by disrupting the biosynthesis of sterols. The content of ergosterol decreases, the content of atypical steric non-planar sterols accumulates. Has a wide spectrum of action.
Highly active towards both the most common and rare pathogens of fungal nail infections:
Dermatophytes: Trichophyton spp., Microsporum spp., Epidermophyton spp.
Yeast fungi: Candida spp., Cryptococcus spp., Malassezia spp. (Pityrosporum spp.)
Molds: Alternaria spp., Scopulariopsis spp., Hendersonula spp.
Fungi from the Dematiaceae family: Cladopsorium spp., Fonsecaea spp., Wangiella spp.
Dimorphic fungi: Coccidioides spp., Histoplasma spp., Sporothrix spp.

Pharmacokinetics: When applied to the nails, it penetrates into the nail plate and further into the nail bed (almost completely within the first 24 hours). The effective concentration remains in the affected nail plate for 7-10 days after the first application.
Systemic absorption is negligible: Cmax in plasma is below the sensitivity limit of determination methods (less than 0.5 ng / ml).

Indications for
application:

Loceryl is used for therapy of patients suffering from onychomycosis caused by various types of fungi sensitive to the action of amorolfine. Loceryl is most effective if no more than 2/3 of the nail plate is affected.
Loceryl can used as a preventative fungal infections of the nail plate.

Mode of application:

Loceryl is intended for external use.. The drug Loceryl and the attached swabs should be stored and used away from open flame. Before each use of the Loceryl preparation, it is recommended to remove the damaged areas of the nail using the attached nail file (it is forbidden to use the nail file that was used to treat the damaged nail on healthy nails). After removing the affected areas of the nail, clean it of dirt and degrease the nail plate with one of the supplied swabs. After that, using a spatula, the solution is applied to the entire surface of the affected nail plate (by dipping the spatula into the solution, contact of the spatula with the neck of the bottle should be avoided). It is not recommended to wash excess solution on the neck of the bottle.
It is recommended to treat all affected nails. After applying the drug, wait 3 minutes until the solution is completely dry. After each use of the drug, wipe the neck of the vial with a swab and tightly close the vial with a lid. After applying the drug, contact of the treated nail plates with tampons moistened with isopropyl alcohol should be avoided.

Course duration and the regimen for the use of the drug Loceryl is determined by the doctor.
As a rule, it is recommended to use the drug 1-2 times a week.
The duration of the course of therapy depends on the rate of nail growth (as a rule, treatment is carried out until the diseased nail is completely replaced with a healthy one). The average duration of therapy with Loceryl for lesions of the nails on the fingers is 6 months, for lesions of the nails on the toes - 9-12 months.
Patients who work with organic solvents, it is recommended to use impervious gloves to prevent contact of the solvent with nails coated with Loceryl solution.
The use of cosmetic varnishes and the use of artificial nails during therapy with Loceryl is not recommended.

Side effects:

Loceryl is usually well tolerated by patients and does not cause the development of undesirable effects. In isolated cases, patients noted the development of burning in the area of ​​​​the nails after the use of the drug Loceryl.

Contraindications:

Loceryl is not prescribed to patients with known hypersensitivity to the active ingredient of the drug and additional ingredients that make up the solution.
Loceryl is not used in pediatric practice.

Interaction
other medicinal
by other means:

Not installed clinically significant interaction of the drug Loceryl with other drugs.

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